Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
نویسندگان
چکیده
منابع مشابه
Hypermethylation in Human Lung Cancer Wnt Inhibitory Factor-1 Is Silenced by Promoter
Aberrant activation of the Wingless-type (Wnt) signaling pathway is associated with a variety of human cancers, and we recently reported the importance of aberrant Wnt signaling in lung cancer. On the other hand, inhibition of Wnt signaling suppresses growth in numerous cell types. Wnt inhibitory factor-1 (WIF-1) is a secreted antagonist that can bind Wnt in the extracellular space and inhibit ...
متن کاملWnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer.
Aberrant activation of the Wingless-type (Wnt) signaling pathway is associated with a variety of human cancers, and we recently reported the importance of aberrant Wnt signaling in lung cancer. On the other hand, inhibition of Wnt signaling suppresses growth in numerous cell types. Wnt inhibitory factor-1 (WIF-1) is a secreted antagonist that can bind Wnt in the extracellular space and inhibit ...
متن کاملWnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma.
It has been reported that the progression of osteosarcoma was closely associated with the aberrant activation of canonical Wnt signaling. Wnt inhibitory factor-1 (WIF-1) is a secreted Wnt inhibitor whose role in human osteosarcoma remains unknown. In this study, WIF-1 expression in NHOst and osteosarcoma cell lines was determined by real-time reverse transcription-PCR, methylation-specific PCR,...
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Ovarian cancer is one of the most frequent female cancer types, it caused the leading mortality of malignancies among Chinese women. However, up to date, we could not yet discover a valid approach for the earlier diagnosis and therapeutic strategy of ovarian cancer. For that reason, more than seventy percent of ovarian cancer patients were already in very late stages (stage III/IV) when diagnos...
متن کاملABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth
Epigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a novel epigenetically silenced target gene. We investigated the epigenetic regulation of ABCB4 in 26 human lung, breast, skin, liver, head and neck cancer cells lines and in pr...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2009
ISSN: 0021-9738
DOI: 10.1172/jci37175